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The SOUL cardiovascular outcomes trial (CVOT) demonstrated a 14% relative reduction in risk of MACE in patients treated with Rybelsus 14 mg orally once daily for approximately 5 years compared to those who received placebo

The recommendation is to use additional contraceptive methods (or switch to non-oral contraception) during GLP-1 therapy, especially during dose changes

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For the primary endpoint of HbA1c reduction, the mean changes from baseline were -1.87%, -1.89%, and -2.07% for the 5 mg, 10 mg, and 15 mg doses, respectively, compared to a +0.04% change for placebo

That's why the new changes people are reporting while taking certain GLP-1 medications have become so concerning

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