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Individual experiences vary significantly

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According to current diagnostic criteria, POTS is defined by a sustained heart rate increase of 30 beats per minute or more (or to above 120 beats per minute) within 10 minutes of standing, in the absence of orthostatic hypotension (a drop in blood pressure of 20/10 mmHg)

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The drug also blocks aldosterone, which leads to sodium excretion, potassium retention, a slight drop in blood pressure, and increased urination