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Its extended duration of action comes from the same pharmacological strategy used in semaglutide and tirzepatide: a fatty acid chain that binds to albumin in the blood, slowing the drug's clearance from the body
Furthermore, vagotomy abolishes the effect of GLP-1 on food intake, while more selective subdiaphragmatic vagal deafferentation attenuates the inhibitory effect of higher doses of intraperitoneal GLP-1 (100 nmol/kg) 136
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The 2.5 mg dose is intended for treatment initiation only and is not considered therapeutically effective for maintenance
GLP-1 injections, also known as glucagon-like peptide-1 receptor agonists, are a treatment originally developed for managing type 2 diabetes
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