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Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice

In the pancreas , GLP-1 supports insulin release to stabilize blood sugar levels

Genetic ablation of GLP-1Rs in alpha cells results in glucose intolerance in vivo and suppression of glucagon secretion in isolated islets at low glucose concentrations [56]

Additional indications under investigation include type 2 diabetes, metabolic dysfunction-associated steatohepatitis (MASH), and potentially cardiovascular risk reduction

Individuals who stopped using GLP-1RAs were categorized into interruption and discontinuation groups

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