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Each time a cell divides, telomeres shorten slightly, and once they become critically short, the cell can no longer replicate efficiently

In: Goldmans Cecil Medicine

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Renal Impairment Dapagliflozin At steady state (20 mg once daily dapagliflozin for 7 days), patients with type 2 diabetes mellitus with mild, moderate, or severe renal impairment (as determined by eGFR) had geometric mean systemic exposures of dapagliflozin that were 45%, 100%, and 200% higher, respectively, as compared to patients with type 2 diabetes mellitus with normal renal function

These can negatively impact circulation, which impacts blood flow and the ability to achieve and maintain erections