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Consequently, an attempt was made to emulate that effect in patients with cirrhosis and HE in a pilot study, and GPB was shown to be capable of reducing NH3 levels in those patients.50 A later study by Rockey et al

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Although the IRE1 inhibitor was inefficient alone, its combination with paclitaxel delayed the time to tumor regrowth after stopping the treatment (Marciniak et al

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