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These neurons produce GLP-1 via posttranslational processing induced by neuroendocrine prohormone convertase [49]
Differential gene expression analysis indicated that exenatide could normalize the aberrant expression of 591 genes in the spinal dorsal horn caused by nerve injury, particularly those related to inflammatory signaling via TNF- and Toll-like receptors
It requires daily injections rather than weekly, which has reduced its use as semaglutide and tirzepatide have become available
Wilmington, DE: AstraZeneca
GLP, or glucagon-like peptide, is a hormone that helps the body release insulin and slow down digestion
Expanding Applications: Clinical trials are actively investigating the use of GLP-1 RAs for a wider range of conditions, including addiction, kidney disease, and neurodegenerative disorders, based on their broad physiological effects
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