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The STEP 1, 2 and 3 trials spanned 68 weeks, whereas the STEP 5 trial took place over 104 weeks

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Combined with reduced metabolic rate during weight loss, this can create a temporary energy deficit that manifests as fatigue, particularly in the first 2-4 weeks of treatment or during dose increases

Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2)

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