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The low intracellular ATP/ADP ratio in the alpha cell leads to ATP-sensitive potassium (KATP) channel closure

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"Without addressing the underlying causes [of obesity ] whether through lifestyle changes, behavioral interventions, or personalized treatment weight loss may not be sustainable, explains Andres Acosta, MD, PhD , associate professor of medicine at Mayo Clinic

The protective effect was seen when compared with both other glucose-lowering drugs and lipid-lowering medications

[DOI] [PubMed] [Google Scholar] 44.Ahangarpour M., Kavianinia I., Harris P.W., Brimble M.A