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doi: 10.3390/nu13072402 62

Metformin alters the gut Microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

Strong preclinical evidence

Targeting IL-10, ZO-1 gene expression and IL-6/STAT-3 trans-signaling by a combination of atorvastatin and mesalazine to enhance anti-inflammatory effects and attenuates progression of oxazolone-induced colitis

Moreover, they show that metformin enhances the expression of the genes encoding the receptors for both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) in mouse islets and also increases the effects of GIP and GLP-1 on insulin secretion from beta cells

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