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Enhancing scalp vascularity via upregulation of vascular endothelial growth factor (VEGF), a protein that encourages new blood vessel formation around follicles demonstrated in laboratory models

Lancet 392(10157):15191529 Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB (2016) LEADER Steering Committee

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reported that Rac1 and Rac2 are essential for the structural integrity of the murine RBC cytoskeleton and are implicated in sickle cell formation [178]