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Acknowledgements Support for VA and Centers for Medicare and Medicaid Services data is provided by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Health Services Research and Development, VA Information Resource Center (Project Number/Data Use Agreement ID Al-Aly-01-A-1)

Tumor growth factor (TGF-)/Smad2 can enhance eNOS transcription in a healthy endothelium but suppress it in chronic inflammation or vascular injury (Saura et al., 2002)