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37 Similarly, in a retrospective cohort study of 3435 people with type 2 diabetes exposed to tirzepatide for 180 days and over compared with a matched unexposed cohort, tirzepatide was associated with an increased risk of new-onset proliferative diabetic retinopathy primarily in those with pre-existing nonproliferative diabetic retinopathy

Together, these pathways highlight how brain health depends on flexible, well-connected neural networks, and why BDNF-related differences may influence how the brain supports cognitive resilience and emotional balance