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Theres also a practical problem: most biologics for RA come in fixed doses that arent adjusted for body weight

Analysis of pooled data To increase the sample size and BW range, five independent experiments totalling 145 rats were pooled into vehicle (V, n = 38), drug (CS + C + S, n = 57) and calorie restriction (WM + PF, n = 50) groups (Extended Data Table 1)

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This fasting requirement is one of the more demanding aspects of GHRP-6 protocols, particularly given that the peptide itself triggers intense hunger within 20-30 minutes of injection