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Side effects by dose level Note: These are approximate rates from clinical trials

5 GLP-1MK-801 is devoid of hallmark MK-801-induced adverse effects

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Additional trials are also underway in participants with type 1 diabetes targeting diverse pathways including oxidative stress, using nicotinamide adenine dinucleotide phosphate oxidase (Nox)-1/4 inhibitors, and the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, using bardoxolone (NCT03366337, NCT03550443) [84, 85]

A year later Edward Albert Sharpey-Schafer, a British physiologist then at University College London (UCL), suggested the pancreatic islets could have a role in controlling the level of blood sugar