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The half-life of natural GLP-1 is approximately 1 to 2 minutes

long-acting incretin analog (39 amino acids) Modification: Lipidated with C20 fatty diacid via Glu-Glu linker on Lys residue

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For instance, nearly 50% of people on these medications experience nausea, whereas vomiting and diarrhoea impact approximately 25% and 30% of users

Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis