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27 Importantly, GLP-1 action is short-lived, with a half-life of just 12 minutes in the bloodstream under normal physiological conditions, after which it is broken down by the enzyme dipeptidyl peptidase IV (DPP-4), resulting in a loss of its biological activity

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in Journal of Nutrition vol

Its particularly important for women of childbearing age, as it helps prevent neural tube defects in the developing fetus

However, rapid weight loss can shift your levothyroxine requirements, causing TSH to drift even on a stable dose

While these effects are most evident in large vessels, the microcirculation of organs such as the retina, kidneys, and testes is also frequently compromised [251,252,253,254,255]