hospitalization required Maintenance of Remission: Immunomodulators (azathioprine, 6-MP, methotrexate) for steroid-dependent or frequently-relapsing disease Biologic monotherapy or combination therapy (biologic + immunomodulator) for moderate-to-severe disease Step-up or top-down approach based on disease severity, patient risk factors, and prior therapy Biologic Therapy Targets: TNF-: Infliximab (IV), adalimumab (SC), certolizumab pegol (SC) IL-12/23: Ustekinumab (IV induction, SC maintenance) Integrin: Vedolizumab (IV) IL-23: Risankizumab (IV induction, SC maintenance) JAK inhibition: Upadacitinib (oral) Surgical Management Surgery is indicated in approximately 7080% of patients with Crohns disease over their lifetime, per StatPearls
Some patients maintain clinically meaningful weight loss at semaglutide 1.0 mg or tirzepatide 5 mg rather than the labeled maximum
If you experience severe nausea or dizziness, avoid alcohol entirely while on this medication
If you have kidney disease, heart failure, or other conditions requiring fluid restriction, consult your healthcare provider for individualized hydration guidance
If you have been following a protocol detailed in our guide to alcohol and GLP-1 medications , similar principles apply to tirzepatide
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