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Other health benefits of the drugs, such as reduced blood pressure, also tend to bounce back after stopping treatment

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To enhance interpretability despite this variability, we pooled outcomes within instruments (HDRS, BDI, MADRS), conducted prespecified subgroup analyses by comparator group and age, used random-effects models, performed leave-one-out sensitivity analyses and publication-bias diagnostics, and applied meta-regression to examine treatment duration and daily dose

IBD has increased significantly in the past few decades, affecting 3.1 million adults in the U.S