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Eur J Neurol 26(7):979985 Engel GL, Marella S, Kaun KR, Wu J, Adhikari P, Kong EC, Wolf FW (2016) Sir2/Sirt1 links acute inebriation to presynaptic changes and the development of alcohol tolerance, preference, and reward

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further notes that NICE CKS guidance states that treatment of B12 deficiency in people with neurologic involvement should include injections on alternate days until there is no further improvement