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Assuming oral bioavailability of ~1% with current formulations that have been FDA-approved compared to injections of the same peptide, the cost-of-goods argument becomes unsustainable for most candidates that might be considered for conversion to the oral route

[21] [22] Examorelin reached phase II clinical trials for the treatment of growth hormone deficiency and congestive heart failure but did not complete development and was never marketed

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This selectivity profile is the compounds primary pharmacological distinction and the main reason it became the preferred GHRP in most combination frameworks

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doi: 10.3945/AJCN.111.023457 158 OckKCSangJCSongWO