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Oral Administration of Cinchonine Improved NAS Score of Ob/Ob-GAN NASH Mice H&E staining (Figure 7A) showed an accumulation of fat droplets in the liver cells of ob/ob-GAN NASH mice compared with the NC group
Side Effects: Sedation Parkinsonism symptoms QT prolongation (may be significant if taking with drugs inhibiting CYP3A4/5 or 2D6) Pharmacokinetics: undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 deuterated active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug twice a day dosing effect half life 9.4 hours (Schneider et al, 2021) HT: Resistant Hypertension
Enzlin, P
PubChem record US Food and Drug Administration
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