Glutamate-cysteine ligase protects cells from ferroptosis by decreasing glutamate levels, converting them to -glutamyl peptides, and boosting GSH production (36) ( Figure 1 )
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Methods - Plasma reduced and oxidised glutathione and red blood cells enzymes including acid phosphatase, methemoglobin reductase and transmembrane reductase were evaluated in Portuguese children with Down syndrome and their siblings, who were used as a control group
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(5) O V Korkushko 1, V Kh Khavinson, V B Shatilo, and L V Magdich (2004) Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people Bulletin of Experimental Biology and Medicine, 2004 Apr, Volume 137 (Issue 4), Pages 389-91