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Acute kidney injury has been reported post-marketing, mainly associated with dehydration from severe gastrointestinal adverse effects

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Rotate patch placement each use for comfort

Zonisamide is a T-type calcium channel blocker antiepileptic, also approved in Japan for the treatment of motor symptoms as an adjunct to levodopa in PD and DLB [185,186,187]

It should be started at 0.6 mg daily for 1 week

Whilst orthostatic hypotension is not a commonly reported adverse effect, indirect mechanismsincluding weight loss, gastrointestinal side effects causing dehydration, and interactions with concurrent medicationsmay contribute to postural blood pressure changes in susceptible individuals