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In the weight-management realm, many individuals without diabetes are being prescribed GLP-1 medications off-label or by newer approvals, for the purpose of weight loss, reduction in fat mass, and improving metabolic health
In the U.S., approved peptide medicines include examples such as semaglutide, tirzepatide, insulin products, teriparatide, calcitonin, and others depending on indication
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These large, complex molecules are inherently unstable and prone to degradation through pathways such as aggregation, deamidation, and oxidation 3