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Third, studies looking at tadalafils safety often establish 20mg as the high dose, leading to a dearth of information about what a dose above 20mg could offer for safety (or efficacy).7 Studies looking at the range of 2.5-20mg have established a linear, dose-dependent relationship with adverse effects, so 22mg should follow that pattern.5 But thats still conjecture at this time

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Interaction terms between treatment and key baseline factors (e.g., baseline epigenetic age acceleration or baseline BMI) were explored to see if the treatment effect varied by these factors