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A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)

Increased Energy Expenditure The stack is investigated for its capacity to increase whole-body metabolic rate and thermogenic activity, with compounds like Rttrutd and 5-Amino-1MQ enhancing mitochondrial respiration

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