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Interestingly, a post-hoc analysis of the Prediabetes Lifestyle Intervention Study (PLIS) suggested that patients achieving prediabetes remission differed from non-responders in improvement in whole body insulin sensitivity, visceral adipose tissue (VAT) and intrahepatic fat rather than insulin secretion upon a similar weight loss 76
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Your labs are monitored throughout, your dose is adjusted based on response and tolerance, and your clinician stays in the loop as your body changes
For retatrutide specifically, 12 mg weekly produces the largest loss but has the highest GI dropout rate, and 9 mg weekly gives nearly the same loss with better tolerability
But its not a magic cure
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