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Accordingly, the role of sUA was confirmed using an in vitro assay in which we demonstrated that sUA stimulated the dose- and time-dependent production of inflammasome-related molecules in the presence of Nlrp3 and Myd88

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Three different classes of aminotransferases evolved prephenate aminotransferase functionality in arogenate-competent microorganisms

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This process is gentle and removes the water that would otherwise facilitate degradation

This impairs ATP synthesis, activates apoptotic pathways, and directly compromises cellular survival in energetically demanding, post-mitotic tissues such as the heart and brain (11-16)