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For context, tirzepatide's SURMOUNT-1 Phase 3 trial showed mean weight reductions of 20.9% at the highest dose (15 mg) over 72 weeks

1978 Mar [cited 2019 Dec 20];27(3):32733

However, emerging evidence suggests some patients experience reduced smoking urges as a secondary benefit

"Molecular basis of the interactions between the disordered Neh4 and Neh5 domains of Nrf2 and CBP/p300 in oxidative stress response"

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