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YuPeng L, YuXue Z, PengFei L, Cheng C, YaShuang Z, DaPeng L, et al

Low- and middle-income countries (LMICs) carry approximately 85% of the global burden, with age-standardized incidence rates often exceeding 1,500 cases per 100,000 population and mortality rates surpassing 40%

Elevated homocysteine levels have been linked to heart disease, stroke and endocrine disorders like hyperinsulinemia

The specific pattern, intensity, and duration of lifestyle intervention in the included studies was not clear, they noted, suggesting that incomplete information about intervention methods may have influenced these findings

Glycophosphatidylinositol-anchored protein Soluble protein attached by a glycolipid anchor (glycophosphatidylinositol) to the cell membrane

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