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Darusentan treatment significantly declined KC numbers likely by downregulating macrophage chemokines Ccl2 and Cx3cL (Viswanathan et al., 2016), probably via inhibiting NF-kB signaling and TNF (Mercurio et al., 2017)

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Weeks 46 : first measurable waist or body-fat changes in responders, based on research community reports

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