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Both the STEP1 and SURMOUNT4 trials included the availability of RDN dietary counseling and recommendations to exercise 150 min/week during the treatment period, but with notable weight regain for most participants upon GLP1 discontinuation without continued nutrition support [18, 20]

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The study confirmed that brain homogenates could also be effectively used to evaluate DSIPs influence on mitochondrial functional state, with DSIP and Deltaran showing comparable activities in both isolated mitochondria and brain homogenates