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The refined models exhibited good model-density fitting and model geometry (see Supplementary information, Table S1 for data and model refinement statistics)

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Children born via assisted reproductive techniques, especially in vitro fertilization with intracytoplasmic sperm injection, have been noted to have higher rates of birth defects than children born via natural conception, but it is still not known whether this reflects problems caused by abnormal sperm, laboratory processing, or other factors

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