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Die Tonizitt einer wssrigen Lsung der erfindungsgemen wasserlslichen Zusammensetzung sollte bei Verabreichung innerhalb des tolerierbaren Bereichs liegen und wird beispielsweise durch Isotonisierungsmittel, wie Natriumchlorid und Mannit, eingestellt

Therefore, timing with meals is irrelevant as it doesnt face degradation from stomach acid or enzymes

The human pilot knee pain study used 2,000mcg intra-articular

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