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I suspect much of these concerns come from categorizing melatonin as a hormone or from early animal and in-vitro studies

Mice were group-housed by gender at 20-24C, 45-65% humidity and exposed to a 12-hour light/12-hour dark period

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The combination addresses what researchers call 'triple defect' diabetes: impaired insulin secretion, reduced insulin sensitivity, and excessive hepatic glucose output

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