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However, in studying how cerebellar Purkinje cells change their responsiveness to a particular stimulus during learning of conditioned responses, it has been shown that these cells can learn the temporal relationship between two paired stimuli

While most of the current studies have been conducted in animal models, the results are impressive

10.1038/s41597-020-0451-5 54 ImamuraH.MonsieursP.JaraM.SandersM.MaesI.VanaerschotM.et al (2020)

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There are four types of HDAC, including class I (HDAC1-3, HDAC8), class II (HDAC4-7, HDAC9-10), class III (SIRT1-7), and class IV (HDAC11) (183)

Continuous daily use can reduce effectiveness over time