doi: 10.1038/s41586-023-05940-w
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Subgroup analysis Semaglutide significantly reduced SBP levels (WMD: 3.01, 95% CI: 4.03 to 2.00) compared with placebo, and its effect was also superior to other AHAs (WMD: 1.85, 95% CI: 2.93 to 0.77) (Fig
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Clinical trials show semaglutide users experience sustained weight loss averaging 10-15% of body weight over 68 weeks, with effects persisting as long as therapy continues
TRIUMPH-4 (445 patients with knee osteoarthritis) reported results in December 2025, showing the 28.7% weight loss figure that made headlines worldwide (Lilly Press Release, Dec 2025)