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For instance, the IMPROVE HF study, which included 15,381 HFrEF patients, identified several factorsfemale sex, no prior myocardial infarction, nonischemic heart failure etiology, and absence of digoxin useas being associated with a greater than 10% improvement in EF 23

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It can cause dangerous blockages, be life-threatening, and may require surgery or urgent medical attention to correct