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Interestingly, the gut metabolic module aspartate degradation I, which converts L-aspartate to oxaloacetate by aspartate aminotransferase, was elevated in SAD patients and the authors hypothesized that bacterial aspartate aminotransferase enzyme activity may represent a link between gut microbiome function and the tryptophan-kynurenine pathway, a key physiological system in psychiatric disorders (Butler et al., 2023)
A once-daily oral version is also in the works for those who dislike injections
[DOI] [PubMed] [Google Scholar] 14.Borude P., Bhushan B., Chavan H
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After trypsinized, cells were resuspended in 3% FBS in PBS and strained through a 40 mM cell strainer (BD Falcon)
Furthermore, combination medications like phentermine-topiramate have been used to treat obesity, though their mechanism of inducing weight loss differs, acting as an appetite suppressant and anti-convulsant, respectively
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