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A 2023 review in Archives of Physiology and Biochemistry found that berberine stimulates GLP-1 secretion by modulating gut microbiota and influencing insulin signaling pathways

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Common Side Effects: Nausea and vomiting (particularly in case of oral use) Salivates because of the bitter taste of sulfur and offensive smell

Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further. Front

The low bioavailability of drugs is still an active area of research, and researchers have investigated several places in the gastrointestinal tract, but an important breakthrough that would be widely applicable to various proteins and peptides have not been achieved

However, you can take several steps to mitigate this side effect