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Previous knee trauma resulting in an ACL or meniscal tear, patellar dislocation, or an intra-articular fracture increases knee OA risk by 5-10%

This suggests that VB has a potent anti-inflammatory activity (67, 69)

Abstract The paradigm of one drug against multiple targets, known as unimolecular polypharmacology, offers the potential to improve efficacy while overcoming some adverse events associated with the treatment

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Taken together, this is a real and reproducible animal signal