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Mounjaro and GLP-1/GIP Receptor Agonists: Newer Hormonal Approach Mounjaro (tirzepatide) represents a newer class that mimics two natural gut hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

Patients should be counselled that regaining weight after stopping GLP-1 RAs can reverse improvements, potentially requiring medications to be resumed

For patients who do respond, Contrave is designed for long-term use

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doi:10.1056/NEJMoa2301972

Talk to your health care provider if you rarely feel hungry or are consistently losing more than about a pound a week