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Decrease of stimulated amylin release precedes impairment of insulin secretion in type II diabetes

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NegriMGentileAde AngelisCMontTPatalanoRColaoAet al

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Interestingly, when ghrelin is administered alone to cells coexpressing D1R and GHSR1a, no increase in cAMP accumulation is observed, while typical levels of Ca 2+ accumulation associated with GHSR1a activation occur (Jiang et al., 2006)

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