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These medicines have undergone rigorous clinical evaluation, have approved SmPCs, and are prescribed with appropriate monitoring and follow-up

[18] Eligibility criteria, treatment duration, and monitoring requirements are defined within this appraisal and associated specialist service frameworks

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One very small study found that people who used semaglutide had lower B12 levels, but these patients also had bariatric surgery prior to using semaglutideso its hard to say if using semaglutide would lead to a B12 deficiency, requiring additional B12

Additionally, they established that according to the WHO definition for MetS, each unit increase in log-transformed IGF-1 concentrations, was associated with a 90.5 % reduction in the risk of MetS [226]