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In accordance with section 1833(t)(2)(B) of the Act, subject to certain exceptions, items and services within an APC group cannot be considered comparable with respect to the use of resources if the highest median cost (or mean cost, if elected by the Secretary) for an item or service in the APC group is more than 2 times greater than the lowest median cost (or mean cost, if elected by the Secretary) for an item or service within the same APC group (referred to as the 2 times rule)

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Implantable drug delivery devices are widely used in diseases that need long term therapy or posepatient compliance problems, such as cardiovascular disease, tuberculosis, diabetes, cancer, and chronic pain management

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Vitamin B12 is a water-soluble vitamin that the body needs for several essential functions