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Gut peptides released in response to chemical or mechanical stimulation can either enter the circulation, reaching central structures involved in appetite regulation, such as the nucleus tractus solitarius, or act locally by activating vagal afferents within the gut or hepatic portal area, thereby eliciting central satiety signals [47]

His vial is 15 mg/mL

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Persistent constipation lasting more than a few days, or symptoms paired with abdominal pain, should be discussed with a healthcare provider