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Hunter SJ, Garvey WT

Current evidence supports glutathione's potential as a depigmenting agent but underscores the need for rigorous, large-scale clinical trials to establish long-term safety, optimal dosing, and standardized applications, and until such data are available, clinicians and consumers should exercise caution to ensure safe and effective dermatological practices, particularly with intravenous use

Many emerging peptides are accessible to licensed healthcare providers through regulated compounding pharmacies

A brief note: This article uses the brand name Ozempic to refer to semaglutide, the drugs active ingredient

Further, patient-specific characteristics, including thickened or dry skin, microangiopathy, and impaired healing in diabetes, could influence microneedle penetration and drug depot formation but are rarely modeled in preclinical models

Make it easy for them: give them a smaller, more manageable size