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Specifically, inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 (IL-6) can enhance the transmission of Wnt signals through various pathways, thereby promoting the progression of ACM (61)

Exposure of mouse oocytes to bisphenol A causes meiotic arrest but not aneuploidy

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Preclinical Development Before semaglutide progressed to first-in-human trials, an extensive non-clinical program was conducted to establish its pharmacodynamic potency, pharmacokinetic behavior, therapeutic efficacy in animal models, and safety margin required by international guidelines

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