Drugs 84 , 227238 (2024)
Some compounding pharmacies and research protocols use slightly different increments, such as 0.25, 0.50, 0.75, 1.0, 1.25, 1.5, 1.75, 2.0, and 2.4mg
When compared head-to-head against Matrixyl 3000 (a widely used synthetic peptide in high-end skincare), GHK-Cu still achieved a 31.6% greater reduction in wrinkle volume
The peptide diffuses into the damaged area where it stimulates collagen synthesis and attracts healing cells
However, some individuals may experience mild side effects such as injection site pain, redness, swelling, nausea, or dizziness
This mechanism raises the critical discontinuation question - does stopping GHK-Cu immediately halt enhanced collagen production returning synthesis rates to pre-treatment baseline, or does the improved dermal environment created during treatment continue supporting elevated collagen production through positive feedback mechanisms where better matrix structure itself promotes ongoing synthesis even without continuous peptide stimulation